Effect of international sensitivity index (ISI) of thromboplastins on precision of international normalised ratios (INR)

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Effect of international sensitivity index (ISI) of thromboplastins on precision of international normalised ratios (INR)

The contribution of the thromboplastin international sensitivity index (ISI) to the interlaboratory coefficient of variation (CV) of the international normalised ratio (INR) with individual reagents was assessed. In theory the precision of the INR should increase with lower ISI values. An empirical relation has been established between the ISI, the INR, and its CV for two rabbit thromboplastins...

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15 صفحه اول

Effect of the choice of WHO International Reference Preparation for thromboplastin on International Normalised Ratios.

AIMS To compare the International Normalised Ratio (INR) obtained directly with the two types of WHO plain International Reference Preparation for thromboplastin in patients treated with coumarin. METHODS Prothrombin times were performed in parallel at four centres using WHO human plain IRP (BCT/253) and rabbit plain IRP (RBT/79). Sixty patients and 20 normal controls were tested at each cent...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1989

ISSN: 0021-9746

DOI: 10.1136/jcp.42.1.92